3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt

Base Information

Chemical Name:3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt
CAS No.:1268383-56-7
Molecular Formula:C₂₉H₂₁F₅N₅O₆*Na
Molecular Weight:653.497
Hs Code.:

3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt

Synonyms:3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt

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Chemical Property of 3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt

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Technology Process of 3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt

There total 9 articles about 3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1268385-19-8
3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid

: 1268383-56-7
3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt

Guidance literature:: With sodium hydrogencarbonate; In water; acetonitrile;

Reference yield:

: 1234790-81-8
4-(propyloxy)-2-(trifluoromethyl)benzaldehyde

: 1268383-56-7
3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydroxylamine / ethanol; water / 2 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 °C

2.2: Reflux

3.1: periodic acid / acetonitrile / 0 - 20 °C

3.2: 0 - 20 °C

4.1: thionyl chloride / 20 °C

5.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

7.1: potassium carbonate / 1,2-dimethoxyethane / 5 h / 20 °C

8.1: periodic acid / acetonitrile / 0 - 20 °C

9.1: sodium hydrogencarbonate / acetonitrile; water

With N-chloro-succinimide; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); hydroxylamine; sodium hydrogencarbonate; potassium carbonate; periodic acid; In tetrachloromethane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1268383-41-0
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

: 1268383-56-7
3-[([2-(2,3-Difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid sodium salt

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1,2-dimethoxyethane / 5 h / 20 °C

2: periodic acid / acetonitrile / 0 - 20 °C

3: sodium hydrogencarbonate / acetonitrile; water

With sodium hydrogencarbonate; potassium carbonate; periodic acid; In 1,2-dimethoxyethane; water; acetonitrile;