3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid

Base Information

Chemical Name:3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid
CAS No.:1268385-19-8
Molecular Formula:C₂₉H₂₂F₅N₅O₆
Molecular Weight:631.516
Hs Code.:

Synonyms:3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid

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Chemical Property of 3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid

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Technology Process of 3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid

There total 8 articles about 3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1268383-45-4
3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate

: 1268385-19-8
3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid

Guidance literature:: 3-hydroxypropyl 2-(2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl)-2-(3-(4-propoxy-2-(trifluoromethyl)phenyl)isoxazol-5-yl)acetate; With periodic acid; In acetonitrile; at 0 - 20 ℃;

With pyridinium chlorochromate; In acetonitrile;

Reference yield:

: 1268383-41-0
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetate

: 1268385-19-8
3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / 1,2-dimethoxyethane / 5 h / 20 °C

2: periodic acid / acetonitrile / 0 - 20 °C

With potassium carbonate; periodic acid; In 1,2-dimethoxyethane; acetonitrile;

Reference yield:

: 1234790-81-8
4-(propyloxy)-2-(trifluoromethyl)benzaldehyde

: 1268385-19-8
3-[([2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetyl)oxy]propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydroxylamine / ethanol; water / 2 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 °C

2.2: Reflux

3.1: periodic acid / acetonitrile / 0 - 20 °C

3.2: 0 - 20 °C

4.1: thionyl chloride / 20 °C

5.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

7.1: potassium carbonate / 1,2-dimethoxyethane / 5 h / 20 °C

8.1: periodic acid / acetonitrile / 0 - 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); hydroxylamine; potassium carbonate; periodic acid; In tetrachloromethane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;