4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)-4-(methoxymethyl)tetrahydro-2H-pyran

Base Information

Chemical Name:4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)-4-(methoxymethyl)tetrahydro-2H-pyran
CAS No.:1541198-06-4
Molecular Formula:C₁₆H₂₁ClO₄
Molecular Weight:312.793
Hs Code.:

Synonyms:4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)-4-(methoxymethyl)tetrahydro-2H-pyran

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Chemical Property of 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)-4-(methoxymethyl)tetrahydro-2H-pyran

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Technology Process of 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)-4-(methoxymethyl)tetrahydro-2H-pyran

There total 5 articles about 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)-4-(methoxymethyl)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1541198-05-3
(4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-yl)methanol

: 74-88-4
methyl iodide

: 1541198-06-4
4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)-4-(methoxymethyl)tetrahydro-2H-pyran

Guidance literature:: (4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-yl)methanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 25 ℃; for 2h;

Reference yield:

: 188813-05-0
3-bromo-5-chloro-benzaldehyde

: 1541198-06-4
4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)-4-(methoxymethyl)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux; Dean-Stark

2.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 25 °C

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 25 °C / Inert atmosphere

4.2: 1 h / 80 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; sodium hydride; toluene-4-sulfonic acid; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; hexane; toluene;

Reference yield:

: 230642-94-1
2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile

: 1541198-06-4
4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)-4-(methoxymethyl)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 25 °C

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 25 °C / Inert atmosphere

3.2: 1 h / 80 °C / Inert atmosphere

With lithium aluminium tetrahydride; n-butyllithium; sodium hydride; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; hexane; toluene;