(5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Base Information

Chemical Name:(5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol
CAS No.:1290629-89-8
Molecular Formula:C₂₃H₂₇ClO₆
Molecular Weight:434.917
Hs Code.:

Synonyms:(5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

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Chemical Property of (5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

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Technology Process of (5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

There total 6 articles about (5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290629-86-5
(5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]octane-1-carboxylic acid ethyl ester

: 1290629-90-1
(5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

: 1290629-89-8
(5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Guidance literature:: (5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]octane-1-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 4h;

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 18h;

Reference yield:

: 1290629-88-7
{(5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-1-yl}-methanol

: 1290629-87-6
{(5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-1-yl}-methanol

: 1290629-90-1
(5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

: 1290629-89-8
(5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Guidance literature:: With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 18h;

Reference yield:

: 1290629-68-3
(2S,3S,4R,5S)-3,4,5-tris-benzyloxy-2-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-6-methylene-tetrahydro-pyran

: 1290629-90-1
(5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

: 1290629-89-8
(5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Guidance literature:: Multi-step reaction with 2 steps

1.1: dirhodium tetraacetate / dichloromethane / 21 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C

2.2: 18 h / 20 °C

With lithium aluminium tetrahydride; dirhodium tetraacetate; In tetrahydrofuran; dichloromethane;