(5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Base Information

Chemical Name:(5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol
CAS No.:1290629-90-1
Molecular Formula:C₂₃H₂₈O₆
Molecular Weight:400.472
Hs Code.:

Synonyms:(5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Suppliers and Price of (5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

There total 11 articles about (5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290629-86-5
(5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]octane-1-carboxylic acid ethyl ester

: 1290629-90-1
(5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

: 1290629-89-8
(5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Guidance literature:: (5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]octane-1-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 4h;

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 18h;

Reference yield:

: 1290629-88-7
{(5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-1-yl}-methanol

: 1290629-87-6
{(5S,6S,7R,8S)-6,7,8-tris-benzyloxy-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-4-oxa-spiro[2.5]oct-1-yl}-methanol

: 1290629-90-1
(5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

: 1290629-89-8
(5S,6R,7R,8S)-5-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Guidance literature:: With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 18h;

Reference yield:

: 461432-26-8,1373321-04-0
dapagliflozin

: 1290629-90-1
(5S,6R,7R,8S)-5-[3-(4-ethoxy-benzyl)-phenyl]-1-hydroxymethyl-4-oxa-spiro[2.5]octane-6,7,8-triol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole; triphenylphosphine; iodine / dichloromethane / 18 h / 0 °C / Reflux

2.1: sodium methylate / methanol / 0 - 45 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 18 h / 20 °C

4.1: dirhodium tetraacetate / dichloromethane / 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C

6.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; iodine; sodium methylate; sodium hydride; triphenylphosphine; dirhodium tetraacetate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;