5-(4-chlorophenyl)-N-hydroxy-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamidine

Base Information

Chemical Name:5-(4-chlorophenyl)-N-hydroxy-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamidine
CAS No.:1345041-84-0
Molecular Formula:C₁₆H₁₆ClN₅O₃S
Molecular Weight:393.854
Hs Code.:

Synonyms:5-(4-chlorophenyl)-N-hydroxy-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-chlorophenyl)-N-hydroxy-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamidine

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Technology Process of 5-(4-chlorophenyl)-N-hydroxy-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamidine

There total 6 articles about 5-(4-chlorophenyl)-N-hydroxy-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1345041-82-8
4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

: 1345041-84-0
5-(4-chlorophenyl)-N-hydroxy-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamidine

Guidance literature:: With hydroxylamine hydrochloride; sodium carbonate; In methanol; at 25 - 30 ℃; for 6h;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 133678-11-2
ethyl 2-oxo-4-(p-chlorophenyl)but-3-enoate

: 1345041-84-0
5-(4-chlorophenyl)-N-hydroxy-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / 0.33 h / 0 °C

4.1: hydroxylamine hydrochloride; sodium carbonate / methanol / 6 h / 25 - 30 °C

With oxalyl dichloride; hydroxylamine hydrochloride; sodium carbonate; ammonium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 1345041-80-6
5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)

: 1345041-84-0
5-(4-chlorophenyl)-N-hydroxy-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxamidine

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2: hydroxylamine hydrochloride; sodium carbonate / methanol / 6 h / 25 - 30 °C

With oxalyl dichloride; hydroxylamine hydrochloride; sodium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.061