(3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid

Base Information

Chemical Name:(3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid
CAS No.:1292290-38-0
Molecular Formula:C₃₃H₃₃NO₃
Molecular Weight:491.63
Hs Code.:

Synonyms:(3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid

Suppliers and Price of (3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Alichem
(S)-3-(4-((4-((2,3-Dihydrospiro[indene-1,4'-piperidin]-1'-yl)methyl)benzyl)oxy)phenyl)hex-4-ynoicacid
1g
$ 1312.00

Alichem
(S)-3-(4-((4-((2,3-Dihydrospiro[indene-1,4'-piperidin]-1'-yl)methyl)benzyl)oxy)phenyl)hex-4-ynoicacid
250mg
$ 556.50

Total 3 raw suppliers

Chemical Property of (3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid

Chemical Property:

Purity/Quality:

99%+, ^*data from raw suppliers

(S)-3-(4-((4-((2,3-Dihydrospiro[indene-1,4'-piperidin]-1'-yl)methyl)benzyl)oxy)phenyl)hex-4-ynoicacid ^*data from reagent suppliers

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Technology Process of (3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid

There total 11 articles about (3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1292291-39-4
ethyl (S)-3-(4-((4-(spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl)oxy)phenyl)hex-4-ynoate

: 1292290-38-0
(3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid

Guidance literature:: ethyl (S)-3-(4-((4-(spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl)oxy)phenyl)hex-4-ynoate; With ethanol; sodium hydroxide; at 90 ℃; for 0.0833333h; Microwave irradiation;

With hydrogenchloride; In water; pH=~ 4;

Reference yield:

: 137730-67-7
spiro(1H-indene-1,4'-piperidine) hydrochloride

: 1292290-38-0
(3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / methanol; water; tetrahydrofuran / 0 - 20 °C / Large scale

1.2: 1 h / 45 °C / Large scale

2.1: lithium aluminium tetrahydride / tetrahydrofuran; 2-methyltetrahydrofuran / 10 - 20 °C / Large scale

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 1 h / 20 °C / Large scale

4.1: sodium hydroxide; water / ethanol / 19 h / 80 °C / Large scale

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; water; sodium hydrogencarbonate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; ethanol; water; toluene;
DOI:10.1021/acs.jmedchem.6b00892

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 1292290-38-0
(3S)-3-(4-{[4-(1′H-spiro[indene-1,4′-piperidine]-1′-ylmethyl)benzyl]oxy}phenyl)hex-4-ynoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / dichloromethane; hexane / 16 h / -78 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: phosphorus tribromide / dichloromethane / 0.25 h / 0 °C

4.1: potassium carbonate / acetonitrile / 16 h / 90 °C

5.1: sodium hydroxide; ethanol / 0.08 h / 90 °C / Microwave irradiation

5.2: pH ~ 4

With ethanol; phosphorus tribromide; diisobutylaluminium hydride; potassium carbonate; caesium carbonate; sodium hydroxide; In hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;