2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone

Base Information

Chemical Name:2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone
CAS No.:938180-01-9
Molecular Formula:C₂₄H₂₁FN₂O₂S
Molecular Weight:420.507
Hs Code.:

Synonyms:2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone

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Chemical Property of 2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone

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Technology Process of 2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone

There total 9 articles about 2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 938177-13-0
5-bromo-2-{3-fluoro-2-[(phenylmethyl)oxy]phenyl}-6-methyl-3-(2-phenylethyl)-4(3H)-pyrimidinone

: 162607-20-7
(5-methylthiophen-2-yl)boronic acid

: 938180-01-9
2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone

Guidance literature:: 5-bromo-2-{3-fluoro-2-[(phenylmethyl)oxy]phenyl}-6-methyl-3-(2-phenylethyl)-4(3H)-pyrimidinone; (5-methylthiophen-2-yl)boronic acid; With sodium carbonate; In 1,4-dioxane; ethanol; water; for 0.166667h;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; at 150 ℃; for 0.555556h; Microwave irradiation;
DOI:10.1021/acsmedchemlett.1c00187

Reference yield: 70.0%

: 938181-77-2
C₃₁H₂₇FN₂O₂S

: 938180-01-9
2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone

Guidance literature:: With hydrogen bromide; acetic acid; at 20 ℃; for 12h;
DOI:10.1021/ol100624p

Reference yield:

: phenylmethyl 3-fluoro-2-[(phenylmethyl)oxy]benzoate

: 938180-01-9
2-(3-fluoro-2-hydroxyphenyl)-6-methyl-5-(5-methyl-2-thienyl)-3-(2-phenylethyl)-4(3H)-pyrimidinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water

2.1: ethyl chloromethyl ether; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 45 h

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 2068.65 Torr / Sealed tube

4.1: titanium(IV)isopropoxide / 36 h / 150 °C / Reflux

4.2: 16 h / 60 °C

5.1: bromine; acetic acid / 16 h

6.1: sodium carbonate / water; ethanol; 1,4-dioxane / 0.17 h

6.2: 0.56 h / 150 °C / Microwave irradiation

With palladium 10% on activated carbon; hydrogen; bromine; titanium(IV)isopropoxide; sodium carbonate; acetic acid; triethylamine; sodium hydroxide; ethyl chloromethyl ether; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1021/acsmedchemlett.1c00187