4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene

Base Information

Chemical Name:4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene
CAS No.:1449689-98-8
Molecular Formula:C₂₅H₂₃ClO₂
Molecular Weight:390.909
Hs Code.:

Synonyms:4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene

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Chemical Property of 4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene

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Technology Process of 4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene

There total 3 articles about 4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1449689-97-7
1-(4-(4-(2-chloroethoxy)phenyl)but-3-yn-1-yl)-3-methoxybenzene

: 66003-76-7
Diphenyliodonium triflate

: 1449689-98-8
4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene

: 1449689-99-9
C₂₅H₂₃ClO₂

Guidance literature:: With 2,6-di-tert-butyl-pyridine; copper(l) chloride; In 1,2-dichloro-ethane; at 50 ℃; for 24h; Overall yield = 74 %; Overall yield = 205 mg; Inert atmosphere; Sealed tube;
DOI:10.1021/ja405972h

Reference yield: 35.0%

: 5470-91-7
3-methoxy-chalcone

: 65136-50-7
4-(2-chloro-ethoxy)-benzoyl chloride

: 1449689-98-8
4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene

Guidance literature:: 3-methoxy-chalcone; 4-(2-chloro-ethoxy)-benzoyl chloride; With aluminum (III) chloride; In dichloromethane; at 0 - 5 ℃; for 1.5h;

With titanium(III) chloride; zinc/copper couple; In 1,2-dimethoxyethane; for 0.75h; Inert atmosphere; Reflux;
DOI:10.1080/00397911.2015.1135957

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1449689-98-8
4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 4 h / 5 - 10 °C

2.1: aluminum (III) chloride / dichloromethane / 1.5 h / 0 - 5 °C

2.2: 0.75 h / Inert atmosphere; Reflux

With aluminum (III) chloride; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1080/00397911.2015.1135957