Nafoxidine hydrochloride

Base Information

Chemical Name:Nafoxidine hydrochloride
CAS No.:1847-63-8
Molecular Formula:C29H31 N O2 . Cl H
Molecular Weight:462.032
Hs Code.:
European Community (EC) Number:439-520-1,606-036-9
NSC Number:70735
UNII:SU8WBD61G1
DSSTox Substance ID:DTXSID30171651
Wikidata:Q27289409
NCI Thesaurus Code:C1448
ChEMBL ID:CHEMBL2106733
Mol file:1847-63-8.mol

Synonyms:Hydrochloride, Nafoxidine;Nafoxidine;Nafoxidine Hydrochloride;U 11,100A;U 11000A;U-11,100A;U-11000A;U11,100A;U11000A

Suppliers and Price of Nafoxidine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Nafoxidine hydrochloride
100mg
$ 1175.00

Sigma-Aldrich
Nafoxidine hydrochloride ≥98% (HPLC)
25mg
$ 478.00

Sigma-Aldrich
Nafoxidine hydrochloride ≥98% (HPLC)
5mg
$ 119.00

Medical Isotopes, Inc.
NafoxidineHCl
10 mg
$ 650.00

Ambeed
1-(2-(4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy)ethyl)pyrrolidinehydrochloride 98%
250mg
$ 328.00

Ambeed
1-(2-(4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy)ethyl)pyrrolidinehydrochloride 98%
100mg
$ 193.00

Ambeed
1-(2-(4-(6-Methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy)ethyl)pyrrolidinehydrochloride 98%
50mg
$ 125.00

Total 22 raw suppliers

Chemical Property of Nafoxidine hydrochloride

Chemical Property:

Vapor Pressure:3.33E-13mmHg at 25°C
Melting Point:165-168℃
Boiling Point:574.5°Cat760mmHg
Flash Point:176.7°C
PSA：21.70000
Density:1.137g/cm³
LogP:6.81500
Storage Temp.:room temp
Solubility.:H2O: ≥8mg/mL
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:461.2121570
Heavy Atom Count:33
Complexity:611

Purity/Quality:

97% ^*data from raw suppliers

Nafoxidine hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/21/22-40
Safety Statements: 22-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(=C(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)OCCN5CCCC5.Cl
Uses Nafoxidine is a non-steroidal antiestrogenic drug that is structurally related to Tamoxifen (T006000). Nafoxidine is a potent estrogen receptor antagonist that exhibits anti-proliferative properties.

Technology Process of Nafoxidine hydrochloride

There total 8 articles about Nafoxidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 123-75-1
pyrrolidine

: 1449689-98-8
4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene

: 1847-63-8
1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride

Guidance literature:: pyrrolidine; 4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene; for 4h; Inert atmosphere; Reflux;

With hydrogenchloride; In ethyl acetate; for 0.5h;
DOI:10.1080/00397911.2015.1135957

Reference yield: 82.0%

: 108-86-1,52753-63-6
bromobenzene

: 6-methoxy-1-[4-(2-(pyrrolidin-1-yl)ethoxy)phenyl]-3,4-dihydronaphthalen-2(1H)-one

: 1847-63-8
1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride

Guidance literature:: bromobenzene; With magnesium; In tetrahydrofuran;

6-methoxy-1-[4-(2-(pyrrolidin-1-yl)ethoxy)phenyl]-3,4-dihydronaphthalen-2(1H)-one; With cerium(III) chloride; In tetrahydrofuran; at -10 - -5 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In water;
DOI:10.1007/s11164-014-1721-7

Reference yield: 61.0%

: 1081-73-8
1-[2-(4-bromophenoxy)ethyl]pyrrolidine

: 1769-84-2
6-methoxy-2-phenyl-1-tetralone

: 1847-63-8
1-{2-[4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine hydrochloride

Guidance literature:: 1-[2-(4-bromophenoxy)ethyl]pyrrolidine; With n-butyllithium; cerium(III) chloride; In tetrahydrofuran; at -78 ℃; for 1.5h;

6-methoxy-2-phenyl-1-tetralone; In tetrahydrofuran; at -78 - 20 ℃; for 17h;

With hydrogenchloride; In diethyl ether; for 0.25h;
DOI:10.1016/j.bmc.2018.04.021