65136-50-7

Upstream product

• 1711-24-6 4-(2-hydroxyethoxy)benzoic acid 
• 10026-13-8 phosphorus pentachloride 
• 65136-51-8 4-(2-chloroethoxy)benzoic acid 
• 79-37-8 oxalyl dichloride 
• 38567-00-9 4-(2-Chloroethoxy)benzoic acid methyl ester 
• 40992-21-0 4-(2-chloro-ethoxy)-benzoic acid ethyl ester 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 3204-73-7 4-(2-hydroxyethoxy)benzoic acid methyl ester 

Downstream Products

• 65136-51-8 4-(2-chloroethoxy)benzoic acid 
• 1622204-11-8 5-((2-(4-(2-(4-hydroxypiperidin-1-yl)ethoxy)benzamide)pyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide 
• 1622206-03-4 C₂₅H₂₃ClN₄O₅ 
• 84449-90-1 Raloxifen 
• 84541-38-8 [6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone 
• 1449689-98-8 4-[4-(2-chloro-ethoxy)-phenyl]-7-methoxy-3-phenyl-1,2-dihydro-naphthalene 
• 1428437-92-6 (2-{4-[7-(benzyl-N-methylamino)heptyloxy]phenyl}benzofuran-3-yl)-[4-(2-chloroethoxy)phenyl]methanone 

Relevant academic research and scientific papers

Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment

To address the multifactorial nature of Alzheimer's Disease (AD), a multi-target-directed ligand approach was herein developed. As a follow-up of our previous studies, a small library of newly designed 2-arylbenzofuran derivatives was evaluated towards ch

Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator

Estrogen receptors (ERs) play a major role in the growth of human breast cancer cells. A selective estrogen receptor down-regulator (SERD) that acts as not only an inhibitor of ligand binding, but also induces the down-regulation of ER, would be useful fo

MONOCYCLIC PYRIDINE DERIVATIVE

The present invention provides a novel compound having FGFR inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein n represents 0 to 2; A represents an arylene group or a heteroarylene group; G represents a single bond, an oxygen atom or —CH2—; E represents a nitrogen-containing non-aromatic heterocycle; R1 represents an alkoxy group or the like; R2 represents a hydrogen atom or the like; and R3 represents a hydrogen atom, an alkyl group, an alkoxy group or the like, with the proviso that when E represents an azetidine ring and R2 or R3 is present on a nitrogen atom on the azetidine ring, the R2 or R3 does not represent a hydrogen atom.

Piperidine nucleophilic substitution without solvent: An efficient synthesis of raloxifene

Mild and high-yielding synthesis is described for raloxifene via piperdine nucleophilic substitution of a new raloxifene intermediate 3-aroyl-2-aryl-substituted benzo[b]thiophenes, which is obtained by acylation of para-substituted benzoyl chlorides and 2-arylbenzo[b]thiophenes. The key step is solvent free and offers valuable advantages, such as low cost, and is suitable for industrial production.

Benzothiophenes and related compounds as estrogen agonists

The invention is a compound of Formula (I): wherein R is —OH, R1is —OH, R2is —H, n is 2 or 3 and X is sulfur, or a pharmaceutically acceptable salt of a compound having Formula (1), or a pharmaceutical composition comprising a compou

Processes for preparing benzothiophenes

The present invention relates to intermediates and processes for preparing benzothiophenes.

Process for preparing benzothiophenes

The present invention relates to intermediates and processes for preparing benzothiophenes of the following formula: wherein Y is chloro, bromo, iodo or -SO2R9; and, R9is C1-C4alkyl, trifluoromethyl,