5-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>benzyl>-2-imino-4-thiazolidinone

Base Information

Chemical Name:5-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>benzyl>-2-imino-4-thiazolidinone
CAS No.:146062-68-2
Molecular Formula:C₁₉H₁₈N₄O₂S
Molecular Weight:366.444
Hs Code.:

Synonyms:5-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>benzyl>-2-imino-4-thiazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>benzyl>-2-imino-4-thiazolidinone

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Technology Process of 5-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>benzyl>-2-imino-4-thiazolidinone

There total 11 articles about 5-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>benzyl>-2-imino-4-thiazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 17356-08-0
thiourea

: 146062-67-1
methyl 2-bromo-3-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>phenyl>propionate

: 146062-68-2
5-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>benzyl>-2-imino-4-thiazolidinone

Guidance literature:: With sodium acetate; In ethanol; for 5h; Heating;
DOI:10.1248/cpb.43.2168

Reference yield:

: (100 ml)-ether

: 144-55-8
sodium hydrogencarbonate

: 146062-67-1
methyl 2-bromo-3-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>phenyl>propionate

: 146062-68-2
5-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>benzyl>-2-imino-4-thiazolidinone

Guidance literature:: With sodium acetate; thiourea; In ethanol;

Reference yield:

: 34107-46-5
6-methyl-3-pyridinemethanol

: 146062-68-2
5-<4-<2-(5-cyanomethyl-2-pyridyl)ethoxy>benzyl>-2-imino-4-thiazolidinone

Guidance literature:: Multi-step reaction with 9 steps

1: 74 percent / NaH / tetrahydrofuran / 1 h / 0 °C

2: 33 percent / H₂O / 8 h / 150 °C

3: 79 percent / NaH / dimethylformamide / 1 h

4: 88 percent / 2N HCl / methanol / 2 h / Heating

5: 85 percent / SOCl₂ / CHCl₃ / 0.5 h / Heating

6: 98 percent / dimethylformamide / 2 h / 60 °C

7: H₂ / 5percent Pd/C / ethyl acetate / 760 Torr

8: 1.) aq. HBr, NaNO₂, 2.) Cu₂O / 1.) acetone, 5 deg C, 2.) acetone

9: 38 percent / NaOAc / ethanol / 5 h / Heating

With copper(I) oxide; hydrogenchloride; thionyl chloride; hydrogen bromide; hydrogen; sodium acetate; sodium hydride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.2168