(2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester
CAS No.:177341-36-5
Molecular Formula:C₁₇H₂₅NO₆
Molecular Weight:339.389
Hs Code.:

Synonyms:(2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester

Suppliers and Price of (2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester

There total 5 articles about (2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 177341-35-4
(2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester

: 177341-36-5
(2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: With lithium borohydride; In tetrahydrofuran; for 5h;
DOI:10.1021/jo9519569

Reference yield:

: 138-60-3
chelidamic acid

: 177341-36-5
(2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2-dimethoxypropane, HCl / 1.) reflux, 4 h, 2.) room temperature, overnight

2: 7.347 g / hydrogen / rhodium on alumina / H₂O / 15 h / 775.7 Torr / Ambient temperature

3: 90 percent / NaHCO₃ / CH₂Cl₂; H₂O / 4 h / Ambient temperature

4: 94 percent / diisopropylethylamine / CH₂Cl₂ / 15 h

5: 93 percent / LiBH₄ / tetrahydrofuran / 5 h

With hydrogenchloride; lithium borohydride; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 2,2-dimethoxy-propane; Rh/Al₂O₃; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo9519569

Reference yield:

: 4-Oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid dimethyl ester; hydrochloride

: 177341-36-5
(2R,4S,6S)-2,6-Bis-hydroxymethyl-4-methoxymethoxy-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 7.347 g / hydrogen / rhodium on alumina / H₂O / 15 h / 775.7 Torr / Ambient temperature

2: 90 percent / NaHCO₃ / CH₂Cl₂; H₂O / 4 h / Ambient temperature

3: 94 percent / diisopropylethylamine / CH₂Cl₂ / 15 h

4: 93 percent / LiBH₄ / tetrahydrofuran / 5 h

With lithium borohydride; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; Rh/Al₂O₃; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo9519569