C₁₂H₁₂O₃

Base Information

• Chemical Name: C₁₂H₁₂O₃
• CAS No.: 854875-53-9
• Molecular Formula: C₁₂H₁₂O₃
• Molecular Weight: 204.225
• Mol file: 854875-53-9.mol

Synonyms:C₁₂H₁₂O₃

Chemical Property of C₁₂H₁₂O₃

Chemical Property:

Purity/Quality:

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Technology Process of C₁₂H₁₂O₃

There total 5 articles about C₁₂H₁₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-iodoacetophenone (2142-70-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → C12H12O3 (854875-53-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 130 ℃; for 2h; Catalytic behavior; Inert atmosphere;

DOI:10.1039/c9ra00460b

Reference yield: 90.0%

2-iodoacetophenone (2142-70-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 2,2'-diacetylbiphenyl (24017-95-6) + C12H12O3 (854875-53-9)

Guidance literature:

With triethylamine; In water; acetonitrile; at 120 ℃; for 3h; Green chemistry;

DOI:10.1016/j.molcata.2015.02.012

Reference yield: 72.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + acetophenone (98-86-2) → C12H12O3 (854875-53-9) + C16H16O5

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; silver(I) hexafluorophosphate; copper diacetate; In 1,2-dichloro-ethane; at 80 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2017.11.058

upstream raw materials:

2-bromophenyl methyl ketone

acrylic acid methyl ester

2-iodoacetophenone

acetophenone