1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

Base Information

Chemical Name:1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one
CAS No.:346577-71-7
Molecular Formula:C₂₈H₃₆N₂O₄
Molecular Weight:464.605
Hs Code.:

Synonyms:1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

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Chemical Property of 1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

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Technology Process of 1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

There total 11 articles about 1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3240-94-6
N-(2-chlorethyl)morpholine

: 948551-98-2
1'-benzyl-5'-ethoxy-4-hydroxyspiro[cyclohexane-1,3'-indolin]-2'-one

: 346577-71-7
1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

Guidance literature:: 1'-benzyl-5'-ethoxy-4-hydroxyspiro[cyclohexane-1,3'-indolin]-2'-one; With sodium hydride; In toluene; at 100 ℃; for 1.5h;

N-(2-chlorethyl)morpholine; In toluene; for 14h; Further stages.; Heating;
DOI:10.1021/jo0004658

Reference yield:

: 15484-91-0
N-benzylidene-4-ethoxyaniline

: 346577-71-7
1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 23.31 g / NaBH₄ / methanol / 2 h / 20 °C

2.1: tetrahydrofuran / 5.5 h / Heating

2.2: 93 percent / MeSO₂N₃; Et₃N / acetonitrile / 12 h

3.1: 84 percent / KOH / acetonitrile; H₂O / 12 h / 20 °C

4.1: 88 percent / Rh₂(OAc)4 / CH₂Cl₂ / 12 h / 20 °C

5.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C

5.2: 90 percent / 1,2-dimethoxy-ethane / 16 h / 20 °C

6.1: 90 percent / PPTS / H₂O; acetone / 20 h / Heating

7.1: NaBH₄ / ethanol / 0 - 20 °C

8.1: NaH / toluene / 1.5 h / 100 °C

8.2: 80 percent / toluene / 14 h / Heating

With potassium hydroxide; sodium tetrahydroborate; pyridinium p-toluenesulfonate; sodium hydride; dirhodium tetraacetate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jo0004658

Reference yield:

: 72753-31-2
N-benzyl-N-(4-ethoxyphenyl)amine

: 346577-71-7
1'-benzyl-5'-ethoxy-4-[2-(4-morpholino)ethoxy]spiro[cyclohexane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 5.5 h / Heating

1.2: 93 percent / MeSO₂N₃; Et₃N / acetonitrile / 12 h

2.1: 84 percent / KOH / acetonitrile; H₂O / 12 h / 20 °C

3.1: 88 percent / Rh₂(OAc)4 / CH₂Cl₂ / 12 h / 20 °C

4.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C

4.2: 90 percent / 1,2-dimethoxy-ethane / 16 h / 20 °C

5.1: 90 percent / PPTS / H₂O; acetone / 20 h / Heating

6.1: NaBH₄ / ethanol / 0 - 20 °C

7.1: NaH / toluene / 1.5 h / 100 °C

7.2: 80 percent / toluene / 14 h / Heating

With potassium hydroxide; sodium tetrahydroborate; pyridinium p-toluenesulfonate; sodium hydride; dirhodium tetraacetate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jo0004658