4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid

Base Information

• Chemical Name: 4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid
• CAS No.: 1095275-26-5
• Molecular Formula: C₁₈H₁₁Cl₂F₃O₃
• Molecular Weight: 403.185
• Mol file: 1095275-26-5.mol

Synonyms:4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid

Chemical Property of 4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid

There total 7 articles about 4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-2-methylbenzoate triethylamine (1095275-08-3) → 4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid (1095275-26-5)

Guidance literature:

With dmap; acetic anhydride; at 60 ℃; for 9h;

Reference yield:

1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one (943437-03-4) + carbon monoxide (201230-82-2) → 4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid (1095275-26-5)

Guidance literature:

1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one; carbon monoxide; With sodium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In 1,2-dimethoxyethane; water; at 110 ℃; for 5.5h; under 7500.75 Torr;

With hydrogenchloride; water; at 20 ℃;

Reference yield:

1-(4-bromophenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butene-1-one (1095275-41-4) + carbon monoxide (201230-82-2) → 4-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butenoyl]-2-methylbenzoic acid (1095275-26-5)

Guidance literature:

With sodium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In (E)-1,2-dimethoxyethene; water; at 110 ℃; for 5.5h; under 7500.75 Torr;

upstream raw materials:

1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one

carbon monoxide

1-(4-bromophenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-butene-1-one

4-(3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl)-2-methylbenzoic acid

Downstream raw materials:

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid