8-bromo-N⁶-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Base Information

• Chemical Name: 8-bromo-N⁶-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
• CAS No.: 143660-34-8
• Molecular Formula: C₄₈H₅₃BrN₇O₈P
• Molecular Weight: 966.869
• Mol file: 143660-34-8.mol

Synonyms:8-bromo-N⁶-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Chemical Property of 8-bromo-N⁶-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-bromo-N⁶-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

There total 8 articles about 8-bromo-N⁶-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 8-bromo-N6-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (143660-33-7) → 8-bromo-N6-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (143660-34-8)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(00)74234-1

Reference yield:

phenoxyacetic anhydride (14316-61-1) → 8-bromo-N6-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (143660-34-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 4 h / Ambient temperature

2: triethylamine, pyridine, water / 0.08 h / Ambient temperature

3: 52 percent / 2 h / Ambient temperature

4: 86 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; N,N-diisopropylamine tetrazolide; water; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)74234-1

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 8-bromo-N6-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (143660-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / 2 h / Ambient temperature

2: 86 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 2 h / Ambient temperature

With N,N-diisopropylamine tetrazolide; In dichloromethane;

DOI:10.1016/S0040-4039(00)74234-1

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

8-bromo-N⁶-phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

phenoxyacetic anhydride

4,4'-dimethoxytrityl chloride