methyl 3-chloro-2,6-difluorobenzoate

Base Information

• Chemical Name: methyl 3-chloro-2,6-difluorobenzoate
• CAS No.: 773873-97-5
• Molecular Formula: C₈H₅ClF₂O₂
• Molecular Weight: 206.576
• Mol file: 773873-97-5.mol

Synonyms:methyl 3-chloro-2,6-difluorobenzoate

Chemical Property of methyl 3-chloro-2,6-difluorobenzoate

Chemical Property:

• Vapor Pressure: 0.0164mmHg at 25°C
• Boiling Point: 255.4±40.0 °C(Predicted)
• Density: 1.398±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-chloro-2,6-difluorobenzoate 97% ^*data from reagent suppliers

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Technology Process of methyl 3-chloro-2,6-difluorobenzoate

There total 2 articles about methyl 3-chloro-2,6-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-2,4-difluorobenzene (1435-44-5) → methyl 3-chloro-2,6-difluorobenzoate (773873-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium tert-butoxide; cesium fluoride; 18-crown-6 ether / 15 h / 120 °C / 760.05 Torr / Sealed tube

2: 2 h / 60 °C / Inert atmosphere

With 18-crown-6 ether; cesium fluoride; lithium tert-butoxide;

DOI:10.1021/acs.orglett.1c03866

Reference yield:

2,6-difluoro-3-chlorobenzoic acid (225104-76-7) + methyl iodide (74-88-4) → methyl 3-chloro-2,6-difluorobenzoate (773873-97-5)

Guidance literature:

at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03866

Reference yield: 29.4%

methyl 3-chloro-2,6-difluorobenzoate (773873-97-5) → methyl 2-amino-5-chloro-6-fluoro-3-nitrobenzoate (1160685-41-5)

Guidance literature:

methyl 3-chloro-2,6-difluorobenzoate; With sulfuric acid; nitric acid; at 0 ℃;

With ammonia; In methanol; water;

upstream raw materials:

1-chloro-2,4-difluorobenzene

2,6-difluoro-3-chlorobenzoic acid

methyl iodide

Downstream raw materials:

methyl 2-amino-5-chloro-6-fluoro-3-nitrobenzoate

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