N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide

Base Information

Chemical Name:N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide
CAS No.:612068-44-7
Molecular Formula:C₁₈H₂₂INO₄
Molecular Weight:443.281
Hs Code.:

Synonyms:N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide

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Chemical Property of N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide

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Technology Process of N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide

There total 11 articles about N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 2-Iodo-4-methoxy-benzoyl chloride

: 612068-38-9
2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethylamine

: 612068-44-7
N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at -40 - 20 ℃; for 4h;
DOI:10.1002/jccs.200300071

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 612068-44-7
N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / Zn powder / tetrahydrofuran / 8 h / Heating

2: 87 percent / LiAlH₄ / diethyl ether / 6 h / 20 °C

3: 38 percent / PPh₃; DEAD / tetrahydrofuran; hexane / 2 h / 20 °C

4: 92 percent / N₂H₄*H₂O / ethanol / 3 h / Heating

5: 67 percent / Et₃N / tetrahydrofuran / 4 h / -40 - 20 °C

With lithium aluminium tetrahydride; hydrazine hydrate; triethylamine; triphenylphosphine; zinc; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; hexane; 1: Reformatzky reaction / 3: Mitsunobu reaction;
DOI:10.1002/jccs.200300071

Reference yield:

: 189509-23-7
8-(2-hydroxyethyl)-1,4-dioxaspiro[4,5]decan-8-ol

: 612068-44-7
N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 38 percent / PPh₃; DEAD / tetrahydrofuran; hexane / 2 h / 20 °C

2: 92 percent / N₂H₄*H₂O / ethanol / 3 h / Heating

3: 67 percent / Et₃N / tetrahydrofuran / 4 h / -40 - 20 °C

With hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; hexane; 1: Mitsunobu reaction;
DOI:10.1002/jccs.200300071