N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxy-N-methylbenzamide

Base Information

Chemical Name:N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxy-N-methylbenzamide
CAS No.:612068-45-8
Molecular Formula:C₁₉H₂₄INO₄
Molecular Weight:457.308
Hs Code.:

Synonyms:N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxy-N-methylbenzamide

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Chemical Property of N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxy-N-methylbenzamide

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Technology Process of N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxy-N-methylbenzamide

There total 13 articles about N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 612068-44-7
N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide

: 74-88-4
methyl iodide

: 612068-45-8
N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxy-N-methylbenzamide

Guidance literature:: N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxybenzamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; for 2h;
DOI:10.1002/jccs.200300071

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 612068-45-8
N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 93 percent / Zn powder / tetrahydrofuran / 8 h / Heating

2.1: 87 percent / LiAlH₄ / diethyl ether / 6 h / 20 °C

3.1: 38 percent / PPh₃; DEAD / tetrahydrofuran; hexane / 2 h / 20 °C

4.1: 92 percent / N₂H₄*H₂O / ethanol / 3 h / Heating

5.1: 67 percent / Et₃N / tetrahydrofuran / 4 h / -40 - 20 °C

6.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

6.2: 99 percent / tetrahydrofuran / 2 h

With lithium aluminium tetrahydride; sodium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; zinc; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; hexane; 1.1: Reformatzky reaction / 3.1: Mitsunobu reaction;
DOI:10.1002/jccs.200300071

Reference yield:

: 189509-23-7
8-(2-hydroxyethyl)-1,4-dioxaspiro[4,5]decan-8-ol

: 612068-45-8
N-[2-(1,4-dioxaspiro[4,5]dec-7-en-8-yl)-ethyl]-2-iodo-4-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 38 percent / PPh₃; DEAD / tetrahydrofuran; hexane / 2 h / 20 °C

2.1: 92 percent / N₂H₄*H₂O / ethanol / 3 h / Heating

3.1: 67 percent / Et₃N / tetrahydrofuran / 4 h / -40 - 20 °C

4.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

4.2: 99 percent / tetrahydrofuran / 2 h

With sodium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; hexane; 1.1: Mitsunobu reaction;
DOI:10.1002/jccs.200300071