ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate

Base Information

Chemical Name:ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate
CAS No.:1092394-10-9
Molecular Formula:C₂₁H₂₂N₆O₄S
Molecular Weight:454.509
Hs Code.:

Synonyms:ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate

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Chemical Property of ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate

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Technology Process of ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate

There total 5 articles about ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1092393-86-6
N-{3-[(6-aminopyridin-3-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

: 16182-04-0
Ethoxycarbonyl isothiocyanate

: 1092394-10-9
ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2013.04.042

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 1092394-10-9
ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C

2: palladium on activated charcoal; hydrogen / methanol / 12 h / 20 °C

3: pyridine / tetrahydrofuran / 2 h / 0 - 20 °C

4: dimethyl sulfoxide / 15 h / 20 °C

With pyridine; palladium on activated charcoal; hydrogen; caesium carbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.042

Reference yield:

: 554-84-7
meta-nitrophenol

: 1092394-10-9
ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C

2: palladium on activated charcoal; hydrogen / methanol / 12 h / 20 °C

3: pyridine / tetrahydrofuran / 2 h / 0 - 20 °C

4: dimethyl sulfoxide / 15 h / 20 °C

With pyridine; palladium on activated charcoal; hydrogen; caesium carbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.042