methyl (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoate

Base Information

• Chemical Name: methyl (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoate
• CAS No.: 1588925-76-1
• Molecular Formula: C₁₉H₂₀O₅
• Molecular Weight: 328.365
• Mol file: 1588925-76-1.mol

Synonyms:methyl (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoate

Chemical Property of methyl (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoate

There total 3 articles about methyl (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoic acid (1588925-73-8) → methyl (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoate (1588925-76-1)

Guidance literature:

With sulfuric acid; for 6h; Reflux; Inert atmosphere;

DOI:10.1007/s10593-014-1442-2

Reference yield:

2,3-dimethyoxybenzaldehyde (86-51-1) → methyl (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoate (1588925-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride; triethylamine / 24 h / Reflux; Inert atmosphere

2: sulfuric acid / 6 h / Reflux; Inert atmosphere

With sulfuric acid; acetic anhydride; triethylamine;

DOI:10.1007/s10593-014-1442-2

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → methyl (E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoate (1588925-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride; triethylamine / 24 h / Reflux; Inert atmosphere

2: sulfuric acid / 6 h / Reflux; Inert atmosphere

With sulfuric acid; acetic anhydride; triethylamine;

DOI:10.1007/s10593-014-1442-2

upstream raw materials:

methanol

(E)-3-(2,3-dimethoxyphenyl)-2-(4-methoxyphenyl)propenoic acid

2,3-dimethyoxybenzaldehyde

4-Methoxyphenylacetic acid

Downstream raw materials:

8-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one