1-[4-(2-Methoxyethyl)phenyl]ethan-1-one

Base Information

• Chemical Name: 1-[4-(2-Methoxyethyl)phenyl]ethan-1-one
• CAS No.: 93205-89-1
• Molecular Formula: C11H14 O2
• Molecular Weight: 178.231
• Hs Code.: 2914509090
• European Community (EC) Number: 297-002-9
• DSSTox Substance ID: DTXSID80239336
• Nikkaji Number: J333.405H
• Wikidata: Q83121678
• Mol file: 93205-89-1.mol

Synonyms:93205-89-1;EINECS 297-002-9;1-[4-(2-METHOXYETHYL)PHENYL]ETHAN-1-ONE;1-(4-(2-Methoxyethyl)phenyl)ethan-1-one;1-[4-(2-methoxyethyl)phenyl]ethanone;DTXSID80239336

Chemical Property of 1-[4-(2-Methoxyethyl)phenyl]ethan-1-one

Chemical Property:

• Vapor Pressure: 0.00761mmHg at 25°C
• Boiling Point: 268.6°C at 760 mmHg
• Flash Point: 110.1°C
• PSA: 26.30000
• Density: 1.008g/cm³
• LogP: 2.07810
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 178.099379685
• Heavy Atom Count: 13
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)CCOC

Technology Process of 1-[4-(2-Methoxyethyl)phenyl]ethan-1-one

There total 4 articles about 1-[4-(2-Methoxyethyl)phenyl]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylene chloride (74-87-3) + 1-<4-(1-hydroxyethyl)phenyl>ethanone (99215-51-7) → 4-methoxyethylacetophenone (93205-89-1)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 50 - 60 ℃; for 4h;

Reference yield:

2-phenylethanol (60-12-8) → 4-methoxyethylacetophenone (93205-89-1)

Guidance literature:

Multi-step reaction with 2 steps

2: NaOH

With sodium hydroxide;

DOI:10.1080/00268948408071842

Reference yield:

β-(4-acetylphenyl)ethyl acetate (73823-79-7) → 4-methoxyethylacetophenone (93205-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 g / sodium hydroxide / ethanol / 5 h / Heating

2: sodium hydroxide / dimethylsulfoxide / 4 h / 50 - 60 °C

With sodium hydroxide; In ethanol; dimethyl sulfoxide;

upstream raw materials:

methylene chloride

1-<4-(1-hydroxyethyl)phenyl>ethanone

2-phenylethanol

β-(4-acetylphenyl)ethyl acetate

Downstream raw materials:

4-(2-methoxyethyl)phenol

Acetic acid 4-(2-methoxy-ethyl)-phenyl ester