(R)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester

Base Information

Chemical Name:(R)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester
CAS No.:153439-42-0
Molecular Formula:C₃₄H₄₃NO₄
Molecular Weight:529.72
Hs Code.:

Synonyms:(R)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester

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Technology Process of (R)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester

There total 2 articles about (R)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76812-02-7
4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid ethyl ester

: 153439-42-0
(R)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester

Guidance literature:: With (+)-diisopinocampheylchloroborane; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

: 207301-37-9
2-[4-((S)-3-[1,3]Dioxolan-2-yl-1-hydroxy-propyl)-phenyl]-2-methyl-propionic acid ethyl ester

: 153439-42-0
(R)-4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Amberlyst

2: 2) NaBH₄ / 1) MeOH, 50 deg C, 2) MeOH, RT

With sodium tetrahydroborate; Amberlyst;
DOI:10.1016/S0040-4039(98)00410-9