4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide

Base Information

Chemical Name:4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide
CAS No.:1363368-18-6
Molecular Formula:C₂₂H₁₉F₂N₃O₄
Molecular Weight:427.407
Hs Code.:

Synonyms:4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide

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Chemical Property of 4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide

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Technology Process of 4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide

There total 10 articles about 4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1363373-75-4
(2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate

: 1363368-18-6
4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide

Guidance literature:: With hydroxylamine hydrochloride; sodium methylate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.joc.6b00589

Reference yield: 82.0%

: 1363368-18-6
4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide

Guidance literature:

Reference yield:

: 119984-88-2
methyl 4-[(4'-aminophenyl)buta-1,3-diyn-1-yl]benzoate

: 1363368-18-6
4-[(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 1 h / Inert atmosphere; Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3: hydroxylamine hydrochloride; sodium methylate / methanol; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.6b00589