(2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate

Base Information

Chemical Name:(2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate
CAS No.:1363373-75-4
Molecular Formula:C₂₃H₂₀F₂N₂O₄
Molecular Weight:426.42
Hs Code.:

Synonyms:(2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate

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Chemical Property of (2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate

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Technology Process of (2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate

There total 10 articles about (2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 728878-27-1
4-[(4'-aminophenyl)buta-1,3-diyn-1-yl]benzoic acid

: (2S,3S)-methyl 2-amino-4,4-difluoro-3-hydroxy-3-methylbutanoate (1R)-(-)-10-camphorsulfonic acid salt

: 1363373-75-4
(2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;
DOI:10.1021/acs.joc.6b00589

Reference yield: 74.0%

: 1363373-75-4
(2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate

Guidance literature:

Reference yield:

: 119984-88-2
methyl 4-[(4'-aminophenyl)buta-1,3-diyn-1-yl]benzoate

: 1363373-75-4
(2S,3S)-methyl 2-{4-[(4-aminophenyl)buta-1,3-diyn-1-yl]benzamido}-4,4-difluoro-3-hydroxy-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 1 h / Inert atmosphere; Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.6b00589