(R)-methyl 4-chloro-3-(1-(methoxymethoxy)-3-(3,4,5-trimethoxyphenyl)propyl)benzoate

Base Information

Chemical Name:(R)-methyl 4-chloro-3-(1-(methoxymethoxy)-3-(3,4,5-trimethoxyphenyl)propyl)benzoate
CAS No.:860638-83-1
Molecular Formula:C₂₂H₂₇ClO₇
Molecular Weight:438.905
Hs Code.:

Synonyms:(R)-methyl 4-chloro-3-(1-(methoxymethoxy)-3-(3,4,5-trimethoxyphenyl)propyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 4-chloro-3-(1-(methoxymethoxy)-3-(3,4,5-trimethoxyphenyl)propyl)benzoate

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Technology Process of (R)-methyl 4-chloro-3-(1-(methoxymethoxy)-3-(3,4,5-trimethoxyphenyl)propyl)benzoate

There total 6 articles about (R)-methyl 4-chloro-3-(1-(methoxymethoxy)-3-(3,4,5-trimethoxyphenyl)propyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 860638-87-5
(R)-5-(3-(5-bromo-2-chlorophenyl)-3-(methoxymethoxy)propyl)-1,2,3-trimethoxybenzene

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 860638-83-1
(R)-methyl 4-chloro-3-(1-(methoxymethoxy)-3-(3,4,5-trimethoxyphenyl)propyl)benzoate

Guidance literature:: With potassium carbonate; bis(triphenylphosphine)palladium(II) chloride; In N,N-dimethyl-formamide; at 95 ℃; under 3800 Torr;
DOI:10.1021/ol0505959

Reference yield:

: 860638-85-3
(S)-1-(5-bromo-2-chlorophenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-yn-1-ol

: 860638-83-1
(R)-methyl 4-chloro-3-(1-(methoxymethoxy)-3-(3,4,5-trimethoxyphenyl)propyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: 94 percent / tetrahydrofuran / 0 - 20 °C

2.1: 95 percent / p-toluenesulfohydrazide; AcONa / 1,2-dimethoxy-ethane; H₂O / Heating

3.1: 82 percent / K₂CO₃ / trans-PdCl₂(PPh₃)2 / dimethylformamide / 95 °C / 3800 Torr

With sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid hydrazide; bis(triphenylphosphine)palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol0505959

Reference yield:

: 860638-84-2
1-(5-bromo-2-chlorophenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-yn-1-one

: 860638-83-1
(R)-methyl 4-chloro-3-(1-(methoxymethoxy)-3-(3,4,5-trimethoxyphenyl)propyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-BBN; (S)-α-pinene / tetrahydrofuran / 20 °C

1.2: 80 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 1.5 h

2.1: NaH / tetrahydrofuran / 1 h / 20 °C

2.2: 94 percent / tetrahydrofuran / 0 - 20 °C

3.1: 95 percent / p-toluenesulfohydrazide; AcONa / 1,2-dimethoxy-ethane; H₂O / Heating

4.1: 82 percent / K₂CO₃ / trans-PdCl₂(PPh₃)2 / dimethylformamide / 95 °C / 3800 Torr

With 9-borabicyclo[3.3.1]nonane dimer; (-)-α-pinene; sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid hydrazide; bis(triphenylphosphine)palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol0505959