Diphenyl[[4-methoxybenzyl[2-bromo-4-methoxy-5-(benzyloxy)benzoyl]amino]methyl]phosphine oxide

Base Information

Chemical Name:Diphenyl[[4-methoxybenzyl[2-bromo-4-methoxy-5-(benzyloxy)benzoyl]amino]methyl]phosphine oxide
CAS No.:206002-18-8
Molecular Formula:C₃₆H₃₃BrNO₅P
Molecular Weight:670.539
Hs Code.:
DSSTox Substance ID:DTXSID501111748
Nikkaji Number:J1.410.828I

Synonyms:DTXSID501111748;2-Bromo-N-[(diphenylphosphinyl)methyl]-4-methoxy-N-[(4-methoxyphenyl)methyl]-5-(phenylmethoxy)benzamide;206002-18-8;Diphenyl[[4-methoxybenzyl[2-bromo-4-methoxy-5-(benzyloxy)benzoyl]amino]methyl]phosphine oxide

Suppliers and Price of Diphenyl[[4-methoxybenzyl[2-bromo-4-methoxy-5-(benzyloxy)benzoyl]amino]methyl]phosphine oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diphenyl[[4-methoxybenzyl[2-bromo-4-methoxy-5-(benzyloxy)benzoyl]amino]methyl]phosphine oxide

Chemical Property:

XLogP3:7.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:12
Exact Mass:669.12797
Heavy Atom Count:44
Complexity:888

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CN(CP(=O)(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)C4=CC(=C(C=C4Br)OC)OCC5=CC=CC=C5

Technology Process of Diphenyl[[4-methoxybenzyl[2-bromo-4-methoxy-5-(benzyloxy)benzoyl]amino]methyl]phosphine oxide

There total 2 articles about Diphenyl[[4-methoxybenzyl[2-bromo-4-methoxy-5-(benzyloxy)benzoyl]amino]methyl]phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27240-64-8
5-Benzyloxy-2-bromo-4-methoxybenzoylchlorid

: 195005-12-0
N-[(diphenylphosphinoyl)methyl]-N-(4-methoxybenzyl)amine

: 206002-18-8
N-[(diphenylphosphinyl)methyl]-N-[(4-methoxyphenyl)methyl]-5-(benzyloxy)-2-bromo-4-methoxybenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jo972247t

Reference yield:

: 24958-42-7
2-bromo-4-methoxy-5-benzyloxy-benzoic acid

: 206002-18-8
N-[(diphenylphosphinyl)methyl]-N-[(4-methoxyphenyl)methyl]-5-(benzyloxy)-2-bromo-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂; DMF / CH₂Cl₂

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; 1: Substitution / 2: Acylation;
DOI:10.1055/s-2000-6385

Reference yield: 81.0%

: 126712-07-0
2-bromo-6-methoxybenzaldehyde

: 206002-18-8
N-[(diphenylphosphinyl)methyl]-N-[(4-methoxyphenyl)methyl]-5-(benzyloxy)-2-bromo-4-methoxybenzamide

: 6-(benzyloxy)-3-[(2-bromo-6-methoxyphenyl)methylene]-2,3-dihydro-5-methoxy-2-[(4-methoxyphenyl)methyl]-1H-isoindol-1-one

Guidance literature:: N-[(diphenylphosphinyl)methyl]-N-[(4-methoxyphenyl)methyl]-5-(benzyloxy)-2-bromo-4-methoxybenzamide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - -30 ℃; for 3.5h;

2-bromo-6-methoxybenzaldehyde; In tetrahydrofuran; toluene; at -30 - 20 ℃; for 0.5h;
DOI:10.1021/jo972247t