C₃₉H₅₀N₂O₇Si

Base Information

• Chemical Name: C₃₉H₅₀N₂O₇Si
• CAS No.: 851121-95-4
• Molecular Formula: C₃₉H₅₀N₂O₇Si
• Molecular Weight: 686.921
• Mol file: 851121-95-4.mol

Synonyms:C₃₉H₅₀N₂O₇Si

Chemical Property of C₃₉H₅₀N₂O₇Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₅₀N₂O₇Si

There total 33 articles about C₃₉H₅₀N₂O₇Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C46H56N2O7Si (851122-06-0) → C39H50N2O7Si (851121-95-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 24h; under 760 Torr;

DOI:10.1021/ja050203t

Reference yield:

2-hydroxymethyl-3-iodo-6-methoxy-5-methyl-phenol (351379-10-7) → C39H50N2O7Si (851121-95-4)

Guidance literature:

Multi-step reaction with 15 steps

1.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

2.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

2.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

3.1: 87 percent / TEA; TBABr; (o-tolyl)3P / Pd(OAc)2 / acetonitrile / 12 h / 80 °C

4.1: 93 percent / H₂; Rh[(COD)-(S,S)-Et-DuPhos]⁽¹⁺⁾*TfO^(1-) / CH₂Cl₂; methanol / 72 h / 20 °C / 5171.48 Torr

5.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 11 h / 20 °C

6.1: 82 percent / sodium hydride / tetrahydrofuran / 15 h / 20 °C

7.1: BOPCl; TEA / CH₂Cl₂ / 72 h / 20 °C

8.1: DDQ; aq. buffer / CH₂Cl₂ / 0.5 h / 20 °C / pH 7.00

9.1: 84 percent / Dess-Martin periodinane; 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

10.1: 59 percent / HCO₂H / 0.2 h / 100 °C

11.1: NaBH₄ / tetrahydrofuran; H₂O / 2 h / 20 °C

12.1: 80 percent / acetic acid; Bu₃SnH; (Ph₃P)2PdCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

13.1: p-TsOH; MgSO₄ / benzene / 4 h / 85 °C

14.1: 90 percent / TEA / CH₂Cl₂ / 0.5 h / 20 °C

15.1: 90 percent / H₂ / Pd/C / ethyl acetate / 24 h / 20 °C / 760 Torr

With 2,6-dimethylpyridine; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; sodium tetrahydroborate; formic acid; (+)-1,2-bis((2S,,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; TEA; tetrabutylammomium bromide; hydrogen; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; magnesium sulfate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; tris-(o-tolyl)phosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 3.1: Jeffery-Heck coupling;

DOI:10.1021/ja050203t

Reference yield:

toluene-4-sulfonic acid 5-iodo-2-methoxy-3-methyl-phenyl ester (351380-16-0) → C39H50N2O7Si (851121-95-4)

Guidance literature:

Multi-step reaction with 17 steps

1.1: 90 percent / aq. NaOH / ethane-1,2-diol / 5 h / Heating

2.1: Et₂AlCl / CH₂Cl₂ / 1 h / 20 °C

2.2: 86 percent / CH₂Cl₂ / 24 h / 20 °C

3.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

4.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

4.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

5.1: 87 percent / TEA; TBABr; (o-tolyl)3P / Pd(OAc)2 / acetonitrile / 12 h / 80 °C

6.1: 93 percent / H₂; Rh[(COD)-(S,S)-Et-DuPhos]⁽¹⁺⁾*TfO^(1-) / CH₂Cl₂; methanol / 72 h / 20 °C / 5171.48 Torr

7.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 11 h / 20 °C

8.1: 82 percent / sodium hydride / tetrahydrofuran / 15 h / 20 °C

9.1: BOPCl; TEA / CH₂Cl₂ / 72 h / 20 °C

10.1: DDQ; aq. buffer / CH₂Cl₂ / 0.5 h / 20 °C / pH 7.00

11.1: 84 percent / Dess-Martin periodinane; 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

12.1: 59 percent / HCO₂H / 0.2 h / 100 °C

13.1: NaBH₄ / tetrahydrofuran; H₂O / 2 h / 20 °C

14.1: 80 percent / acetic acid; Bu₃SnH; (Ph₃P)2PdCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

15.1: p-TsOH; MgSO₄ / benzene / 4 h / 85 °C

16.1: 90 percent / TEA / CH₂Cl₂ / 0.5 h / 20 °C

17.1: 90 percent / H₂ / Pd/C / ethyl acetate / 24 h / 20 °C / 760 Torr

With 2,6-dimethylpyridine; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; formic acid; (+)-1,2-bis((2S,,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; TEA; tetrabutylammomium bromide; hydrogen; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylaluminium chloride; sodium hydride; magnesium sulfate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; tris-(o-tolyl)phosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethylene glycol; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 5.1: Jeffery-Heck coupling;

DOI:10.1021/ja050203t

upstream raw materials:

C₄₆H₅₆N₂O₇Si

2-hydroxymethyl-3-iodo-6-methoxy-5-methyl-phenol

toluene-4-sulfonic acid 5-iodo-2-methoxy-3-methyl-phenyl ester

(2-benzyloxy-6-iodo-3-methoxy-4-methyl-phenyl)-methanol

Downstream raw materials:

C₃₉H₄₈N₂O₈Si

C₃₉H₄₆N₂O₉Si

C₃₉H₄₈N₂O₉Si