1-(4-Chloro-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

Base Information

Chemical Name:1-(4-Chloro-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one
CAS No.:109334-78-3
Molecular Formula:C₂₃H₁₆ClN₃O
Molecular Weight:385.853
Hs Code.:

Synonyms:1-(4-Chloro-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

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Chemical Property of 1-(4-Chloro-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

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Technology Process of 1-(4-Chloro-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

There total 4 articles about 1-(4-Chloro-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 109334-71-6
1-(4-Chloro-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

: 74-88-4
methyl iodide

: 109334-78-3
1-(4-Chloro-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

Guidance literature:: With triethylammonium hydroxide; In methanol; for 48h; Heating;
DOI:10.1021/jm00393a009

Reference yield:

: 109334-61-4
ethyl (2-nitrobenzoyl)benzoylacetate

: 109334-78-3
1-(4-Chloro-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / Et₃N / methanol / 6 h / Heating

2: 1.) H₂ / 1.) 10percent Pd/C / 1.) EtOAc, 50 psi, 12 h, 2.) 150 deg C, 30 min

3: 15 percent / triethylammonium hydroxide / methanol / 48 h / Heating

With triethylammonium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00393a009

Reference yield:

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 109334-78-3
1-(4-Chloro-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / Et₃N / methanol / 6 h / Heating

2: 1.) H₂ / 1.) 10percent Pd/C / 1.) EtOAc, 50 psi, 12 h, 2.) 150 deg C, 30 min

3: 15 percent / triethylammonium hydroxide / methanol / 48 h / Heating

With triethylammonium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00393a009