2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid

Base Information

• Chemical Name: 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid
• CAS No.: 142374-16-1
• Molecular Formula: C₃₀H₄₀N₂O₇
• Molecular Weight: 540.657
• Mol file: 142374-16-1.mol

Synonyms:2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid

Chemical Property of 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid

There total 7 articles about 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester (142374-15-0) → 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid (142374-16-1)

Guidance literature:

With sodium hydroxide; In methanol; for 16h;

DOI:10.1021/jm00042a007

Reference yield: 88.0%

Z-L-Tyr-OH (1164-16-5) + tert-butyl 4-(3-bromopropyl)piperidine-1-carboxylate (164149-27-3) → 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid (142374-16-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ol010282n

Reference yield:

4-(3-Hydroxypropyl)pyridine (2629-72-3) → 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid (142374-16-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / H₂; AcOH / 10percent Pd/C / 20 °C / 2585.81 Torr

2: 92 percent / 1N NaOH / dioxane

3: 80 percent / CBr₄; PPh₃ / CH₂Cl₂

4: 88 percent / NaH / dimethylformamide

With sodium hydroxide; carbon tetrabromide; hydrogen; sodium hydride; acetic acid; triphenylphosphine; 10percent Pd/C; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol010282n

upstream raw materials:

methyl 2-(S)-amino>-3-<4-<<piperidin-4-yl>propyl>oxy>phenyl>propionic acid ester

Z-L-Tyr-OH

tert-butyl 4-(3-bromopropyl)piperidine-1-carboxylate

3-(piperidin-4-yl)propan-1-ol

Downstream raw materials:

methyl 3-(S)-amino>-4-<4-<<piperidin-4-yl>propyl>oxy>phenyl>butanoate

4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-methoxycarbonyl-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester

4-{3-[4-((S)-2-Benzyloxycarbonylamino-3-carboxy-propyl)-phenoxy]-propyl}-piperidine-1-carboxylic acid tert-butyl ester

4-(3-{4-[(S)-2-(Butane-1-sulfonylamino)-3-carboxy-propyl]-phenoxy}-propyl)-piperidine-1-carboxylic acid tert-butyl ester