{2-[2,5-Dimethoxy-4-((R)-1-phenyl-3-phenylselanyl-propyl)-phenoxy]-ethyl}-trimethyl-silane

Base Information

Chemical Name:{2-[2,5-Dimethoxy-4-((R)-1-phenyl-3-phenylselanyl-propyl)-phenoxy]-ethyl}-trimethyl-silane
CAS No.:828933-82-0
Molecular Formula:C₂₈H₃₆O₃SeSi
Molecular Weight:527.638
Hs Code.:

Synonyms:{2-[2,5-Dimethoxy-4-((R)-1-phenyl-3-phenylselanyl-propyl)-phenoxy]-ethyl}-trimethyl-silane

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Chemical Property of {2-[2,5-Dimethoxy-4-((R)-1-phenyl-3-phenylselanyl-propyl)-phenoxy]-ethyl}-trimethyl-silane

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Technology Process of {2-[2,5-Dimethoxy-4-((R)-1-phenyl-3-phenylselanyl-propyl)-phenoxy]-ethyl}-trimethyl-silane

There total 8 articles about {2-[2,5-Dimethoxy-4-((R)-1-phenyl-3-phenylselanyl-propyl)-phenoxy]-ethyl}-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2179-79-5
phenyl selenocyanate

: 720712-37-8
(R)-3-[2,5-Dimethoxy-4-(2-trimethylsilanyl-ethoxy)-phenyl]-3-phenyl-propan-1-ol

: 828933-82-0
{2-[2,5-Dimethoxy-4-((R)-1-phenyl-3-phenylselanyl-propyl)-phenoxy]-ethyl}-trimethyl-silane

Guidance literature:: With tributylphosphine; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1021/jo048703c

Reference yield:

: 51061-83-7
2,4-dihydroxy-5-methoxybenzaldehyde

: 828933-82-0
{2-[2,5-Dimethoxy-4-((R)-1-phenyl-3-phenylselanyl-propyl)-phenoxy]-ethyl}-trimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: PPh₃; DIAD / tetrahydrofuran / 12 h / 20 °C

2: Hunig's base; DMAP / CH₂Cl₂

3: 83 percent / diethyl ether / 3 h / -78 - 20 °C

4: 91 percent / H₂O; CSA / acetonitrile; tetrahydrofuran / 6 h / 100 °C

5: 82 percent / LiAlH₄ / tetrahydrofuran / 0.08 h / 0 °C

6: 90 percent / diethyl ether / 12 h

7: 95 percent / PBu₃ / tetrahydrofuran / 5 h / 20 °C

With dmap; lithium aluminium tetrahydride; tributylphosphine; di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/jo048703c

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 828933-82-0
{2-[2,5-Dimethoxy-4-((R)-1-phenyl-3-phenylselanyl-propyl)-phenoxy]-ethyl}-trimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: PPh₃; DIAD / tetrahydrofuran / 12 h / 20 °C

2: Hunig's base; DMAP / CH₂Cl₂

3: 83 percent / diethyl ether / 3 h / -78 - 20 °C

4: 91 percent / H₂O; CSA / acetonitrile; tetrahydrofuran / 6 h / 100 °C

5: 82 percent / LiAlH₄ / tetrahydrofuran / 0.08 h / 0 °C

6: 90 percent / diethyl ether / 12 h

7: 95 percent / PBu₃ / tetrahydrofuran / 5 h / 20 °C

With dmap; lithium aluminium tetrahydride; tributylphosphine; di-isopropyl azodicarboxylate; camphor-10-sulfonic acid; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/jo048703c