methyl 2-((4-propylbenzyl)amino)acetate

Base Information

• Chemical Name: methyl 2-((4-propylbenzyl)amino)acetate
• CAS No.: 1360803-34-4
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Mol file: 1360803-34-4.mol

Synonyms:methyl 2-((4-propylbenzyl)amino)acetate

Chemical Property of methyl 2-((4-propylbenzyl)amino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((4-propylbenzyl)amino)acetate

There total 10 articles about methyl 2-((4-propylbenzyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-(iodomethyl)-4-propylbenzene (1360803-33-3) + methoxycarbonylmethylamine (616-34-2) → methyl 2-((4-propylbenzyl)amino)acetate (1360803-34-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene (275386-60-2) → methyl 2-((4-propylbenzyl)amino)acetate (1360803-34-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 1H-imidazole / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 2 h / 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 15001.5 Torr

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

7.1: sodium iodide / acetone / 0.25 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With 1H-imidazole; methanol; n-butyllithium; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane (1093190-17-0) → methyl 2-((4-propylbenzyl)amino)acetate (1360803-34-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 15001.5 Torr

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.1: sodium iodide / acetone / 0.25 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With n-butyllithium; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;

upstream raw materials:

[2-(4-{[(tert-butyldimethylsilyl)oxy]methyl}phenyl)ethynyl]trimethylsilane

4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene

tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane

4-n-propylbenzyl alcohol

Downstream raw materials:

methyl 2-(N-(4-propylbenzyl)-2-(4-propylphenyl)acetamido)acetate