4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

Base Information

Chemical Name:4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester
CAS No.:1232234-94-4
Molecular Formula:C₂₄H₂₄ClN₃O₅S₂
Molecular Weight:534.057
Hs Code.:

Synonyms:4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

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Chemical Property of 4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

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Technology Process of 4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

There total 12 articles about 4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232234-93-3
4-(3-chloro-phenyl)-2-[6-(4-hydroxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

: 124-63-0
methanesulfonyl chloride

: 1232234-94-4
4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1232234-37-5
4-dimethoxymethyl-2-fluoro-1-nitro-benzene

: 1232234-94-4
4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: hydrogenchloride; water / acetonitrile / 0.5 h / 60 °C

3.1: ammonium chloride; zinc / tetrahydrofuran / 1 h

4.1: acetic acid / 1 h

4.2: pH 9

5.1: phenyllithium / tetrahydrofuran / -78 °C

5.2: 20 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2585.81 Torr

7.1: boron dimethyl-trifluoro sulphide / acetonitrile / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; boron dimethyl-trifluoro sulphide; water; hydrogen; ammonium chloride; caesium carbonate; acetic acid; phenyllithium; N-ethyl-N,N-diisopropylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1H-1,3-benzodiazole-6-carbaldehyde

: 1232234-94-4
4-(3-chloro-phenyl)-2-[6-(4-methanesulfonyloxy-butyl)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

1.2: 1 h / 20 °C

2.1: phenyllithium / tetrahydrofuran / -78 °C

2.2: 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2585.81 Torr

4.1: boron dimethyl-trifluoro sulphide / acetonitrile / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With boron dimethyl-trifluoro sulphide; hydrogen; sodium hydride; phenyllithium; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;