2,4-dichloro-N-(2-pyridinyl)benzamide

Base Information

• Chemical Name: 2,4-dichloro-N-(2-pyridinyl)benzamide
• CAS No.: 326883-43-6
• Molecular Formula: C₁₂H₈Cl₂N₂O
• Molecular Weight: 267.114
• European Community (EC) Number: 661-817-1
• Nikkaji Number: J3.209.046J
• Mol file: 326883-43-6.mol

Synonyms:2,4-dichloro-N-pyridin-2-ylbenzamide;2,4-dichloro-N-(2-pyridinyl)benzamide;326883-43-6;Oprea1_337040;Oprea1_481082;CBDivE_011812;STK148274;AKOS001317802;2,4-dichloro-N-(pyridin-2-yl)benzamide;AG-668/02784030;SR-01000200767;SR-01000200767-1;Z85526826

Chemical Property of 2,4-dichloro-N-(2-pyridinyl)benzamide

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 266.0013683
• Heavy Atom Count: 17
• Complexity: 275

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=NC(=C1)NC(=O)C2=C(C=C(C=C2)Cl)Cl

Technology Process of 2,4-dichloro-N-(2-pyridinyl)benzamide

There total 3 articles about 2,4-dichloro-N-(2-pyridinyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-aminopyridine (504-29-0) + 1-(2,4-dichlorophenyl)ethan-1-one (2234-16-4) → 2, 4-dichloro-N-(pyridin-2-yl)benzamide (326883-43-6)

Guidance literature:

With oxygen; sodium docusate; copper(l) chloride; In water; at 80 ℃; for 3h; under 760.051 Torr; chemoselective reaction; Green chemistry;

DOI:10.1016/j.tet.2019.130536

Reference yield: 79.0%

2-aminopyridine (504-29-0) + 2,4-dichlorophenacyl bromide (2631-72-3) → 2, 4-dichloro-N-(pyridin-2-yl)benzamide (326883-43-6)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In toluene; at 100 ℃; for 2h;

DOI:10.1039/c9ra06724h

Reference yield: 66.0%

2-aminopyridine (504-29-0) + 2,4-dichlorobenzaldeyhde (874-42-0) → 2, 4-dichloro-N-(pyridin-2-yl)benzamide (326883-43-6)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Green chemistry;

DOI:10.1016/j.tet.2013.05.072

upstream raw materials:

2-aminopyridine

2,4-dichlorobenzaldeyhde

1-(2,4-dichlorophenyl)ethan-1-one

2,4-dichlorophenacyl bromide