3-(2-chlorophenyl)-1-[2-(N,N-diethylamino)ethyl]carbamoylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H, 3H)-quinazolinedione

Base Information

Chemical Name:3-(2-chlorophenyl)-1-[2-(N,N-diethylamino)ethyl]carbamoylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H, 3H)-quinazolinedione
CAS No.:81087-65-2
Molecular Formula:C₂₇H₃₃ClN₄O₅
Molecular Weight:529.036
Hs Code.:

Synonyms:3-(2-chlorophenyl)-1-[2-(N,N-diethylamino)ethyl]carbamoylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H, 3H)-quinazolinedione

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Chemical Property of 3-(2-chlorophenyl)-1-[2-(N,N-diethylamino)ethyl]carbamoylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H, 3H)-quinazolinedione

Chemical Property:

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Technology Process of 3-(2-chlorophenyl)-1-[2-(N,N-diethylamino)ethyl]carbamoylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H, 3H)-quinazolinedione

There total 6 articles about 3-(2-chlorophenyl)-1-[2-(N,N-diethylamino)ethyl]carbamoylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H, 3H)-quinazolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 81087-61-8
3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

: 100-36-7
N,N-diethylethylenediamine

: 81087-65-2
3-(2-chlorophenyl)-1-[2-(N,N-diethylamino)ethyl]carbamoylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H, 3H)-quinazolinedione

Guidance literature:: at 80 ℃; for 8h;
DOI:10.1248/cpb.39.1753

Reference yield: 62.0%

: unsym-diethylethylenediamine

: 81087-61-8
3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

: 81087-65-2
3-(2-chlorophenyl)-1-[2-(N,N-diethylamino)ethyl]carbamoylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H, 3H)-quinazolinedione

Guidance literature:

Reference yield:

: 3320-83-0
o-chlorophenyl isocyanate

: 81087-65-2
3-(2-chlorophenyl)-1-[2-(N,N-diethylamino)ethyl]carbamoylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H, 3H)-quinazolinedione

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 14 h / Ambient temperature

2: conc. HCl / ethanol / 2 h / Heating

3: 83 percent / NaH / dimethylformamide / 2 h / 70 °C

4: 78 percent / 8 h / 80 °C

With hydrogenchloride; sodium hydride; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1753