3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

Base Information

Chemical Name:3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione
CAS No.:81087-61-8
Molecular Formula:C₂₃H₂₃ClN₂O₆
Molecular Weight:458.898
Hs Code.:

Synonyms:3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

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Chemical Property of 3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

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Technology Process of 3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

There total 4 articles about 3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 81087-59-4
3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione

: 105-39-5
chloroacetic acid ethyl ester

: 81087-61-8
3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 70 ℃; for 2h;
DOI:10.1248/cpb.39.1753

Reference yield:

: 3320-83-0
o-chlorophenyl isocyanate

: 81087-61-8
3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 14 h / Ambient temperature

2: conc. HCl / ethanol / 2 h / Heating

3: 83 percent / NaH / dimethylformamide / 2 h / 70 °C

With hydrogenchloride; sodium hydride; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1753

Reference yield:

: 67467-27-0
2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid

: 81087-61-8
3-(2-chlorophenyl)-1-ethoxycarbonylmethyl-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 14 h / Ambient temperature

2: conc. HCl / ethanol / 2 h / Heating

3: 83 percent / NaH / dimethylformamide / 2 h / 70 °C

With hydrogenchloride; sodium hydride; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.1753