(4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester

Base Information

Chemical Name:(4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester
CAS No.:113949-52-3
Molecular Formula:C₂₃H₂₅NO₄S₂
Molecular Weight:443.588
Hs Code.:

Synonyms:(4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester

Suppliers and Price of (4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester

There total 7 articles about (4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 14204-24-1
N-(phenylthio)succinimide

: 80586-33-0
(1S,4R)-1-<3-(benzoylthio)-2-methyl-1-oxopropyl>-4-hydroxy-L-proline methyl ester

: 113949-52-3
(4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester

Guidance literature:: With tributylphosphine; In benzene; for 22h;
DOI:10.1021/jm00401a014

Reference yield:

: 81653-77-2
(S)-4-phenylthio-L-proline

: 113949-52-3
(4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / trimethylsilyl chloride / 10 h / Heating

2: 83 percent / 1-hydroxybenzotriazole; N,N-diisopropylethylamine; EDAC*HCl / tetrahydrofuran / 5 h

3: 3.0 g / N,N-diisopropylethylamine / 0.08 h / 60 °C

With chloro-trimethyl-silane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 3: Michael addition;
DOI:10.1016/j.bmc.2003.10.054

Reference yield:

: 67-56-1
methanol

: 81938-43-4
calcium (2S,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylate

: 113949-52-3
(4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/jms.392