2-(3-(benzyloxy)prop-1-yn-1-yl)-2-(((tert-butyldimethylsilyl)oxy)-methyl)-1-tosylaziridine

Base Information

Chemical Name:2-(3-(benzyloxy)prop-1-yn-1-yl)-2-(((tert-butyldimethylsilyl)oxy)-methyl)-1-tosylaziridine
CAS No.:1373263-74-1
Molecular Formula:C₂₆H₃₅NO₄SSi
Molecular Weight:485.72
Hs Code.:

Synonyms:2-(3-(benzyloxy)prop-1-yn-1-yl)-2-(((tert-butyldimethylsilyl)oxy)-methyl)-1-tosylaziridine

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Chemical Property of 2-(3-(benzyloxy)prop-1-yn-1-yl)-2-(((tert-butyldimethylsilyl)oxy)-methyl)-1-tosylaziridine

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Technology Process of 2-(3-(benzyloxy)prop-1-yn-1-yl)-2-(((tert-butyldimethylsilyl)oxy)-methyl)-1-tosylaziridine

There total 3 articles about 2-(3-(benzyloxy)prop-1-yn-1-yl)-2-(((tert-butyldimethylsilyl)oxy)-methyl)-1-tosylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1373264-21-1
((5-(benzyloxy)-2-methylenepent-3-yn-1-yl)oxy)(tert-butyl)dimethylsilane

: 55962-05-5
[N-(p-tolylsulfonyl)imino]phenyliodinane

: 1373263-74-1
2-(3-(benzyloxy)prop-1-yn-1-yl)-2-(((tert-butyldimethylsilyl)oxy)-methyl)-1-tosylaziridine

Guidance literature:: With tetrakis(acetonitrile)copper(I) perchlorate; In acetonitrile; at 20 ℃; Molecular sieve; Ionic liquid;
DOI:10.1021/jo300294r

Reference yield:

: 4039-82-1
Benzyl propargyl ether

: 1373263-74-1
2-(3-(benzyloxy)prop-1-yn-1-yl)-2-(((tert-butyldimethylsilyl)oxy)-methyl)-1-tosylaziridine

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / tetrahydrofuran / 50 °C / Inert atmosphere

2: tetrakis(acetonitrile)copper(I) perchlorate / acetonitrile / 20 °C / Molecular sieve; Ionic liquid

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(acetonitrile)copper(I) perchlorate; diisopropylamine; In tetrahydrofuran; acetonitrile; 1: Sonogashira coupling;
DOI:10.1021/jo300294r

Reference yield:

: 147455-22-9
1-(tert-butyldimethylsilyloxy)-2-iodoprop-2-ene

: 1373263-74-1
2-(3-(benzyloxy)prop-1-yn-1-yl)-2-(((tert-butyldimethylsilyl)oxy)-methyl)-1-tosylaziridine

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / tetrahydrofuran / 50 °C / Inert atmosphere

2: tetrakis(acetonitrile)copper(I) perchlorate / acetonitrile / 20 °C / Molecular sieve; Ionic liquid

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(acetonitrile)copper(I) perchlorate; diisopropylamine; In tetrahydrofuran; acetonitrile; 1: Sonogashira coupling;
DOI:10.1021/jo300294r