Technology Process of (E)-3,4-bis(tert-butoxycarbonylamino)styrylboronic acid
There total 5 articles about (E)-3,4-bis(tert-butoxycarbonylamino)styrylboronic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
di-tert-butyl(4-ethynyl-1,2-phenylene)dicarbamate;
With
dimethylsulfide borane complex; (+)-α-pinene;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 5.17h;
With
acetaldehyde;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 20h;
Reflux;
With
water;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran / 72 h / Inert atmosphere
2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 0.17 h / Inert atmosphere
2.2: 18 h / 70 °C / Inert atmosphere; Microwave irradiation; sealed tube
3.1: potassium carbonate / tetrahydrofuran; methanol / 3 h / 20 °C
4.1: dimethylsulfide borane complex; (+)-α-pinene / tetrahydrofuran / 5.17 h / 0 - 20 °C
4.2: 20 h / 0 - 20 °C / Reflux
4.3: 3 h / 20 °C
With
copper(l) iodide; dimethylsulfide borane complex; (+)-α-pinene; sodium hydrogencarbonate; potassium carbonate; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran / 72 h / Inert atmosphere
2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 0.17 h / Inert atmosphere
2.2: 18 h / 70 °C / Inert atmosphere; Microwave irradiation; sealed tube
3.1: potassium carbonate / tetrahydrofuran; methanol / 3 h / 20 °C
4.1: dimethylsulfide borane complex; (+)-α-pinene / tetrahydrofuran / 5.17 h / 0 - 20 °C
4.2: 20 h / 0 - 20 °C / Reflux
4.3: 3 h / 20 °C
With
copper(l) iodide; dimethylsulfide borane complex; (+)-α-pinene; sodium hydrogencarbonate; potassium carbonate; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol;
