13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid

Base Information

Chemical Name:13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid
CAS No.:945686-04-4
Molecular Formula:C₂₉H₃₀N₂O₆S
Molecular Weight:534.633
Hs Code.:

Synonyms:13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid

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Chemical Property of 13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid

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Technology Process of 13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid

There total 8 articles about 13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 945686-03-3
methyl 13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylate

: 945686-04-4
13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid

Guidance literature:: methyl 13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylate; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 60 ℃; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃;

Reference yield:

: 494799-18-7
methyl 3-cyclohexyl-1H-indole-6-carboxylate

: 945686-04-4
13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 2.5 h / 0 - 5 °C

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

2.2: 1 h / 0 - 20 °C

3.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve

4.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.25 h

4.2: 4 h / 85 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

6.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C

7.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 60 °C

7.2: 0.17 h

7.3: 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 60 °C

With lithium hydroxide; sodium hydroxide; pyridinium hydrobromide perbromide; water; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 945686-04-4
13-cyclohexyl-10-((cyclopropylsulfonyl)carbamoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

1.2: 1 h / 0 - 20 °C

2.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve

3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.25 h

3.2: 4 h / 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

5.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2.5 h / 20 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 60 °C

6.2: 0.17 h

6.3: 20 °C

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 60 °C

With lithium hydroxide; sodium hydroxide; water; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;