S-Methyl-N-(2-methylbenzoyl)-S-phenylsulfoximide

Base Information

• Chemical Name: S-Methyl-N-(2-methylbenzoyl)-S-phenylsulfoximide
• CAS No.: 54090-91-4
• Molecular Formula: C₁₅H₁₅NO₂S
• Molecular Weight: 273.356
• Mol file: 54090-91-4.mol

Synonyms:N-(2-methylbenzoyl)-S-methyl-S-phenyl sulfoximine

Chemical Property of S-Methyl-N-(2-methylbenzoyl)-S-phenylsulfoximide

Chemical Property:

• Boiling Point: 434.0±38.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-Methyl-N-(2-methylbenzoyl)-S-phenylsulfoximide

There total 15 articles about S-Methyl-N-(2-methylbenzoyl)-S-phenylsulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ortho-toluoyl chloride (933-88-0) + S-methyl-S-phenylsulfoximine (4381-25-3) → N-(2-methylbenzoyl)-S-methyl-S-phenyl sulfoximine (54090-91-4)

Guidance literature:

S-methyl-S-phenylsulfoximine; With sodium hydride; In dichloromethane; mineral oil; at 20 ℃; Inert atmosphere;

ortho-toluoyl chloride; In dichloromethane; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/chem.201200092

Reference yield: 84.0%

ortho-methylphenyl iodide (615-37-2) + carbon monoxide (201230-82-2) + S-methyl-S-phenylsulfoximine (4381-25-3) → N-(2-methylbenzoyl)-S-methyl-S-phenyl sulfoximine (54090-91-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

DOI:10.1039/c6ra05334c

Reference yield: 72.0%

S-methyl-S-phenylsulfoximine (4381-25-3) + 2-methylphenyl aldehyde (529-20-4) → N-(2-methylbenzoyl)-S-methyl-S-phenyl sulfoximine (54090-91-4)

Guidance literature:

With N-Bromosuccinimide; In 1,2-dichloro-ethane; at 80 ℃; for 0.416667h; Microwave irradiation;

DOI:10.1055/s-0039-1691589

upstream raw materials:

methyl-phenyl-thioether

racemic methyl phenyl sulfoxide

ortho-toluoyl chloride

S-methyl-S-phenylsulfoximine

Downstream raw materials:

N-[2-acetoxy-6-methylbenzoyl]-S-methyl-S-phenylsulfoximine

N-[2-(4'-methylbenzenesulfonamido)-6-methylbenzoyl]-S-methyl-S-phenylsulfoximine

N-[2-(4'-nitrobenzenesulfonamido)-6-methylbenzoyl]-S-methyl-S-phenylsulfoximine

N-[2-(4'-trifluoromethylbenzenesulfonamido)-6-methylbenzoyl]-S-methyl-S-phenylsulfoximine

Refernces

• 1、 Ambala, Srinivas,Arvidsson, Per I.,Govender, Thavendran,Kruger, Hendrik G.,Naicker, Tricia,Rajbongshi, Kamal K.. "Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions". . p. 1279 - 1286. Retrieved 2020/04/15.
• 2、 Muneeswara, Madithedu,Kotha, Surya Srinivas,Sekar, Govindasamy. "Iron-Catalyzed One-Pot N-Aroylation of NH-Sulfoximines with Methylarenes through Benzylic C-H Bond Oxidation". . p. 1541 - 1549. Retrieved 2016/06/01.