trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline

Base Information

• Chemical Name: trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline
• CAS No.: 1061737-21-0
• Molecular Formula: C₄₀H₃₆N₂O₄
• Molecular Weight: 608.737
• Mol file: 1061737-21-0.mol

Synonyms:trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline

Chemical Property of trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline

There total 1 articles about trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.9%

(2S,4R) Fmoc-4-amino-1-boc-pyrrolidine-2-carboxylic acid (1061737-18-5) + 4-methyltrityl chloride (23429-44-9) → trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline (1061737-21-0)

Guidance literature:

(2S,4R) Fmoc-4-amino-1-boc-pyrrolidine-2-carboxylic acid; 4-methyltrityl chloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

With methanol; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Further stages.;

DOI:10.1021/jo8012258

Reference yield: 65.0%

N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea (947748-47-2) + trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline (1061737-21-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + trifluoroacetic acid (76-05-1) → 2C2HF3O2*C18H32N6O4

Guidance literature:

Multistep reaction.;

DOI:10.1021/jo8012258

upstream raw materials:

(2S,4R) Fmoc-4-amino-1-boc-pyrrolidine-2-carboxylic acid

4-methyltrityl chloride