trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline

Base Information

Chemical Name:trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline
CAS No.:1061737-21-0
Molecular Formula:C₄₀H₃₆N₂O₄
Molecular Weight:608.737
Hs Code.:

Synonyms:trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline

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Technology Process of trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline

There total 1 articles about trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.9%

: 1061737-18-5
(2S,4R) Fmoc-4-amino-1-boc-pyrrolidine-2-carboxylic acid

: 23429-44-9
4-methyltrityl chloride

: 1061737-21-0
trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline

Guidance literature:: (2S,4R) Fmoc-4-amino-1-boc-pyrrolidine-2-carboxylic acid; 4-methyltrityl chloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

With methanol; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Further stages.;
DOI:10.1021/jo8012258