C₃₁H₃₁ClN₂O₄

Base Information

• Chemical Name: C₃₁H₃₁ClN₂O₄
• CAS No.: 1609644-34-9
• Molecular Formula: C₃₁H₃₁ClN₂O₄
• Molecular Weight: 531.051
• Mol file: 1609644-34-9.mol

Synonyms:C₃₁H₃₁ClN₂O₄

Chemical Property of C₃₁H₃₁ClN₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₃₁ClN₂O₄

There total 2 articles about C₃₁H₃₁ClN₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-amino-N-((1R,2R)-2-hydroxy-1,2-diphenylethyl)-N-methylacetamide (1609644-25-8) + 4-benzyloxy-3-chlorobenzaldehyde (66422-84-2) → C31H31ClN2O4 (1609644-34-9) + C31H31ClN2O4

Guidance literature:

2-amino-N-((1R,2R)-2-hydroxy-1,2-diphenylethyl)-N-methylacetamide; With lithium chloride; In tetrahydrofuran; at 23 ℃; for 0.00833333h; Inert atmosphere;

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 0 ℃; for 0.5h; Inert atmosphere;

4-benzyloxy-3-chlorobenzaldehyde; In tetrahydrofuran; at -78 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201400928

Reference yield:

tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate (1609644-58-7) → C31H31ClN2O4 (1609644-34-9) + C31H31ClN2O4

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1.67 h / 0 - 23 °C / Inert atmosphere

2.1: lithium chloride / tetrahydrofuran / 0.01 h / 23 °C / Inert atmosphere

2.2: 0.5 h / -78 - 0 °C / Inert atmosphere

2.3: -78 °C / Inert atmosphere

With trifluoroacetic acid; lithium chloride; In tetrahydrofuran; dichloromethane; 2.3: |Aldol Addition;

DOI:10.1002/anie.201400928

Reference yield: 94.0%

C31H31ClN2O4 (1609644-34-9) → (1R,2R)-2-(methylamino)-1,2-diphenylethan-1-ol (1081548-91-5) + C16H15ClNO4(1-)*Na(1+) (1609644-46-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water; at 23 ℃; for 20.0833h; Inert atmosphere; Cooling with ice;

DOI:10.1002/anie.201400928

upstream raw materials:

2-amino-N-((1R,2R)-2-hydroxy-1,2-diphenylethyl)-N-methylacetamide

4-benzyloxy-3-chlorobenzaldehyde

tert-butyl (2-(((1R,2R)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-2-oxoethyl)carbamate

Downstream raw materials:

(1R,2R)-2-(methylamino)-1,2-diphenylethan-1-ol

C₁₆H₁₅ClNO₄^(1-)*Na⁽¹⁺⁾