Thioacetic acid S-[(S)-3,3-dimethyl-2-(methyl-phenyl-amino)-butyl] ester

Base Information

• Chemical Name: Thioacetic acid S-[(S)-3,3-dimethyl-2-(methyl-phenyl-amino)-butyl] ester
• CAS No.: 219639-26-6
• Molecular Formula: C₁₅H₂₃NOS
• Molecular Weight: 265.42
• Mol file: 219639-26-6.mol

Synonyms:Thioacetic acid S-[(S)-3,3-dimethyl-2-(methyl-phenyl-amino)-butyl] ester

Chemical Property of Thioacetic acid S-[(S)-3,3-dimethyl-2-(methyl-phenyl-amino)-butyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thioacetic acid S-[(S)-3,3-dimethyl-2-(methyl-phenyl-amino)-butyl] ester

There total 5 articles about Thioacetic acid S-[(S)-3,3-dimethyl-2-(methyl-phenyl-amino)-butyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tiolacetic acid (507-09-5) + (S)-N-methyl-N-phenyl-2-amino-3,3-dimethylbutan-1-ol (219639-21-1) → Thioacetic acid S-[(S)-3,3-dimethyl-2-(methyl-phenyl-amino)-butyl] ester (219639-26-6)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1016/S0957-4166(98)00344-9

Reference yield:

(S)-2-amino-3,3-dimethyl-butyric acid methyl ester (63038-26-6) → Thioacetic acid S-[(S)-3,3-dimethyl-2-(methyl-phenyl-amino)-butyl] ester (219639-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / Cu(OAc)2 / CH₂Cl₂ / 24 h / Ambient temperature

2: tetrahydrofuran / 24 h / 60 °C

3: 51 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

4: 92 percent / DIAD, Ph₃P / tetrahydrofuran / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; copper diacetate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0957-4166(98)00344-9

Reference yield:

triphenylbismuth(V) diacetate (28899-97-0,7239-60-3) → Thioacetic acid S-[(S)-3,3-dimethyl-2-(methyl-phenyl-amino)-butyl] ester (219639-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / Cu(OAc)2 / CH₂Cl₂ / 24 h / Ambient temperature

2: tetrahydrofuran / 24 h / 60 °C

3: 51 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

4: 92 percent / DIAD, Ph₃P / tetrahydrofuran / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; copper diacetate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0957-4166(98)00344-9

upstream raw materials:

tiolacetic acid

(S)-N-methyl-N-phenyl-2-amino-3,3-dimethylbutan-1-ol

(S)-2-amino-3,3-dimethyl-butyric acid methyl ester

triphenylbismuth(V) diacetate