(3R,4R)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Base Information

Chemical Name:(3R,4R)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one
CAS No.:1380402-69-6
Molecular Formula:C₃₁H₂₇NO₄S
Molecular Weight:509.626
Hs Code.:

Synonyms:(3R,4R)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

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Chemical Property of (3R,4R)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

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Technology Process of (3R,4R)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

There total 5 articles about (3R,4R)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-82-2
phenylacetic acid

: 1268249-59-7
C₂₃H₂₁NO₃S

: 1380402-69-6
(3R,4R)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: C₃₁H₂₇NO₄S

Guidance literature:: With pivaloyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Overall yield = 77 %; stereoselective reaction;
DOI:10.1021/acscatal.5b02121

Reference yield:

: 201230-82-2
carbon monoxide

: C₂₃H₂₃NO₃S

: 100-39-0
benzyl bromide

: 1380402-69-6
(3R,4R)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: 4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: With (+)-(R,S)-Fused-BTM; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 30 ℃; for 12h; under 750.075 Torr; Overall yield = 51 %; Overall yield = 26 mg; stereoselective reaction;
DOI:10.1002/anie.201901501

Reference yield:

: 63591-85-5
phenylacetic acid N-hydroxysuccinimide ester

: 1268249-59-7
C₂₃H₂₁NO₃S

: 1380402-69-6
(3R,4R)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: 4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

: (3S,4S)-4-(4-methoxyphenyl)-3,6-diphenyl-1-tosyl-3,4-dihydropyridin-2(1H)-one

Guidance literature:: With (R)-5-benzyl-2-phenyl-6,7-dihydro-5H-pyrrplp[2,1-c][1,2,4]triazol-2-ium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 10 ℃; for 24h; Overall yield = 82 %; stereoselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1002/asia.201500959