Technology Process of 1-benzyl-3-{[methoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-methyl}-6-oxo-1,6-dihydro-pyridine-2-carboxylic acid ethyl ester
There total 5 articles about 1-benzyl-3-{[methoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-methyl}-6-oxo-1,6-dihydro-pyridine-2-carboxylic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: thionyl chloride / 5 h / -20 °C / Reflux
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
3: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 0 °C / Cooling with ice
4: dichloro-acetic acid / water / 1 h / Reflux
5: potassium carbonate; lithium bromide; tetrabutylammomium bromide / toluene; water / 0.67 h / 80 °C
6: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux
7: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C
With
dichloro-acetic acid; N-Bromosuccinimide; thionyl chloride; tetrabutylammomium bromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; lithium bromide; trichlorophosphate; dibenzoyl peroxide;
In
tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 0 °C / Cooling with ice
2: dichloro-acetic acid / water / 1 h / Reflux
3: potassium carbonate; lithium bromide; tetrabutylammomium bromide / toluene; water / 0.67 h / 80 °C
4: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux
5: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C
With
dichloro-acetic acid; N-Bromosuccinimide; tetrabutylammomium bromide; potassium carbonate; sodium iodide; lithium bromide; trichlorophosphate; dibenzoyl peroxide;
In
tetrachloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dichloro-acetic acid / water / 1 h / Reflux
2: potassium carbonate; lithium bromide; tetrabutylammomium bromide / toluene; water / 0.67 h / 80 °C
3: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux
4: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C
With
dichloro-acetic acid; N-Bromosuccinimide; tetrabutylammomium bromide; potassium carbonate; sodium iodide; lithium bromide; dibenzoyl peroxide;
In
tetrachloromethane; water; N,N-dimethyl-formamide; toluene;
