(5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone

Base Information

• Chemical Name: (5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone
• CAS No.: 1381883-40-4
• Molecular Formula: C₂₂H₁₇BrClN₃O₂
• Molecular Weight: 470.753
• Mol file: 1381883-40-4.mol

Synonyms:(5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone

Chemical Property of (5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone

There total 4 articles about (5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-chloronicotinic acid (2942-59-8) + C16H15BrN2O (202827-81-4) → (5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone (1381883-40-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 8h; Reflux;

DOI:10.1016/j.bmc.2012.04.047

Reference yield: 75.0%

→ (5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone (1381883-40-4)

Guidance literature:

With hydrazine hydrate; In propan-1-ol; at 90 ℃; for 10h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 45 ℃; for 12h;

Reference yield:

4-bromo-4'-methoxychalcone (92873-00-2) → (5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-chloropyridin-3-yl)methanone (1381883-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / isopropyl alcohol / 8 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 8 h / Reflux

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; isopropyl alcohol;

DOI:10.1016/j.bmc.2012.04.047

upstream raw materials:

4-bromo-4'-methoxychalcone

2-chloronicotinic acid

C₁₆H₁₅BrN₂O

4-bromo-benzaldehyde