(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

Base Information

Chemical Name:(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine
CAS No.:135068-31-4
Molecular Formula:C₃₇H₄₉NO₆S
Molecular Weight:635.865
Hs Code.:

Synonyms:(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

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Chemical Property of (2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

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Technology Process of (2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

There total 13 articles about (2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 67-56-1
methanol

: 135068-36-9
(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-((E)-2-methoxy-vinyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

: 135068-31-4
(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

Guidance literature:: With camphor-10-sulfonic acid;
DOI:10.1016/S0040-4039(00)74295-X

Reference yield:

: 19803-37-3
Tetrakis(benzyloxy)titanium

: 135068-31-4
(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

Guidance literature:: Multi-step reaction with 11 steps

2: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂

3: NaH / diethyl ether

4: 90 percent / DIBAH / CH₂Cl₂

5: PDC / dimethylformamide

6: tetrahydrofuran

7: 81 percent / 144 h / 40 °C

8: 92 percent / LAH / diethyl ether

9: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂ / -60 °C

10: tetrahydrofuran

11: 93 percent / CSA

With lithium aluminium tetrahydride; dipyridinium dichromate; oxalyl dichloride; camphor-10-sulfonic acid; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74295-X

Reference yield:

: 89461-51-8
[(2S,3S)-3-pentyloxiran-2-yl]methanol

: 135068-31-4
(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

Guidance literature:: Multi-step reaction with 11 steps

2: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂

3: NaH / diethyl ether

4: 90 percent / DIBAH / CH₂Cl₂

5: PDC / dimethylformamide

6: tetrahydrofuran

7: 81 percent / 144 h / 40 °C

8: 92 percent / LAH / diethyl ether

9: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂ / -60 °C

10: tetrahydrofuran

11: 93 percent / CSA

With lithium aluminium tetrahydride; dipyridinium dichromate; oxalyl dichloride; camphor-10-sulfonic acid; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74295-X