1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea

Base Information

• Chemical Name: 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea
• CAS No.: 1227780-08-6
• Molecular Formula: C₂₅H₃₀N₆O₃
• Molecular Weight: 462.552

Synonyms:1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea

Chemical Property of 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea

Chemical Property:

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Technology Process of 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea

There total 1 articles about 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

1-(tert-butyl)-3-(6-(3,5-dimethoxyphenyl)-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7-yl)urea (918106-28-2) + 1-amino-pent-4-yne hydrochloride → 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea (1227780-08-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 50 ℃; for 20h; Inert atmosphere;

DOI:10.1039/b923882d

Reference yield: 81.0%

2-azidomethylpyridine (609770-35-6) + 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea (1227780-08-6) → 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(3-(1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)propylamino)pyrido[2,3-d]pyrimidin-7-yl)urea (1227780-11-1)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; In water; tert-butyl alcohol; at 20 ℃;

DOI:10.1039/b923882d

Reference yield: 81.0%

N-benzyl-3-azido-pyrrolidine + 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(pent-4-ynylamino)pyrido[2,3-d]pyrimidin-7-yl)urea (1227780-08-6) → 1-(2-(3-(1-(1-benzylpyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)propylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea (1227780-10-0)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; In water; tert-butyl alcohol; at 20 ℃;

DOI:10.1039/b923882d

upstream raw materials:

1-(tert-butyl)-3-(6-(3,5-dimethoxyphenyl)-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7-yl)urea

Downstream raw materials:

1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(3-(1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)propylamino)pyrido[2,3-d]pyrimidin-7-yl)urea

1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(3-(1-((1-methylpiperidin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)propylamino)pyrido[2,3-d]pyrimidin-7-yl)urea

1-(2-(3-(1-(1-benzylpyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)propylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea

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